| South Africa |
| 16 |
| England |
| 15 |
| 24 November 2012 | ||||||
| Twickenham, London | ||||||
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| Captain: Jean de Villiers | Referee: Nigel Owens (Wales) | |||||
| Coach: Heyneke Meyer | Attendance: 81151 | |||||
| Position | Player | Province | Age | Prev Tests | Scoring |
| Loose-head Prop | Gürthro Steenkamp | Toulouse | 31 | 39 | |
| Hooker | Adriaan Strauss | Cheetahs | 27 | 20 | |
| Tight-head Prop | Jannie du Plessis | Sharks | 30 | 41 | |
| Lock | Eben Etzebeth | WP | 21 | 10 | |
| Lock | Juandré Kruger | Blue Bulls | 27 | 7 | |
| Flank | Francois Louw | Bath | 27 | 16 | |
| Flank | Willem Alberts | Sharks | 28 | 19 | 1 try |
| Eighthman | Duane Vermeulen | WP | 26 | 6 | |
| Scrumhalf | Ruan Pienaar | Ulster | 28 | 62 | |
| Flyhalf | Pat Lambie | Sharks | 22 | 19 | 1 conversion, 3 penalties |
| Left Wing | Francois Hougaard | Blue Bulls | 24 | 26 | |
| Inside Centre (C) | Jean de Villiers | WP | 31 | 83 | |
| Outside Centre | Juan de Jongh | WP | 24 | 13 | |
| Right Wing | JP Pietersen | Sharks | 26 | 47 | |
| Full Back | Zane Kirchner | Blue Bulls | 28 | 23 | |
| Reserve | Pat Cilliers | Sharks | 25 | 5 | |
| Reserve | Marcell Coetzee | Sharks | 21 | 11 | |
| Reserve | Heinke van der Merwe | Leinster | 27 | 3 | |
| Reserve | Flip van der Merwe | Blue Bulls | 27 | 22 | |
| Reserve | Schalk Brits | Saracens | 31 | 4 |
| England: 5 penalties |